{"id":6468,"date":"2023-05-17T10:45:38","date_gmt":"2023-05-17T10:45:38","guid":{"rendered":"https:\/\/energia.imdea.org\/?post_type=portfolio&#038;p=6468"},"modified":"2023-06-02T09:14:03","modified_gmt":"2023-06-02T09:14:03","slug":"6468","status":"publish","type":"portfolio","link":"http:\/\/energia.imdea.org\/en\/porfolio\/6468\/","title":{"rendered":"NeuroMOF: Self-propelled Metal-Organic Framework nanocarriers as promising brain delivery platform"},"content":{"rendered":"<div  class=\"tatsu-h25u8z2cwv2kj2v6 tatsu-section  tatsu-bg-overlay   tatsu-clearfix\" data-title=\"\"  data-headerscheme=\"background--dark\"><div class='tatsu-section-pad clearfix' data-padding='{\"d\":\"0px 0px 0px 0px\"}' data-padding-top='0px'><div class=\"tatsu-row-wrap  tatsu-wrap tatsu-row-one-col tatsu-row-has-one-cols tatsu-medium-gutter tatsu-reg-cols  tatsu-clearfix tatsu-h25u8z2d0d2tcbvp\" ><div  class=\"tatsu-row \" ><div  class=\"tatsu-column  tatsu-bg-overlay tatsu-one-col tatsu-column-image-none tatsu-column-effect-none  tatsu-h25u8z2d544qfkw2\"  data-parallax-speed=\"0\" style=\"\"><div class=\"tatsu-column-inner \" ><div class=\"tatsu-column-pad-wrap\"><div class=\"tatsu-column-pad\" ><div  class=\"tatsu-module tatsu-text-block-wrap tatsu-h25u8z2d8b91f3jc  \"><div class=\"tatsu-text-inner tatsu-align-center  clearfix\" ><style>.tatsu-h25u8z2d8b91f3jc.tatsu-text-block-wrap .tatsu-text-inner{width: 100%;text-align: left;}.tatsu-h25u8z2d8b91f3jc.tatsu-text-block-wrap{margin: 200px 0px 0px 0px;}<\/style>\n<h4><span style=\"font-size: 28pt; color: #ffffff;\"><strong>NeuroMOF: Self-propelled Metal-Organic Framework nanocarriers as promising brain delivery platform\u00a0<\/strong><\/span><\/h4>\n<\/div><\/div><\/div><\/div><div class = \"tatsu-column-bg-image-wrap\"><div class = \"tatsu-column-bg-image\" ><\/div><\/div><div class=\"tatsu-overlay tatsu-column-overlay tatsu-animate-none\" ><\/div><\/div><style>.tatsu-row > .tatsu-h25u8z2d544qfkw2.tatsu-column{width: 100%;}.tatsu-h25u8z2d544qfkw2.tatsu-column > .tatsu-column-inner > .tatsu-column-overlay{mix-blend-mode: normal;}.tatsu-h25u8z2d544qfkw2 > .tatsu-column-inner > .tatsu-top-divider{z-index: 9999;}.tatsu-h25u8z2d544qfkw2 > .tatsu-column-inner > .tatsu-bottom-divider{z-index: 9999;}.tatsu-h25u8z2d544qfkw2 > .tatsu-column-inner > .tatsu-left-divider{z-index: 9999;}.tatsu-h25u8z2d544qfkw2 > .tatsu-column-inner > .tatsu-right-divider{z-index: 9999;}@media only screen and (max-width:1377px) {.tatsu-row > .tatsu-h25u8z2d544qfkw2.tatsu-column{width: 100%;}}@media only screen and (min-width:768px) and (max-width: 1024px) {.tatsu-row > .tatsu-h25u8z2d544qfkw2.tatsu-column{width: 100%;}}@media only screen and (max-width: 767px) {.tatsu-row > .tatsu-h25u8z2d544qfkw2.tatsu-column{width: 100%;}}<\/style><\/div><\/div><\/div><\/div><div class=\"tatsu-section-background-wrap\"><div class = \"tatsu-section-background\" ><\/div><\/div><div class=\"tatsu-overlay tatsu-section-overlay\"><\/div><style>.tatsu-h25u8z2cwv2kj2v6 .tatsu-section-background{background-image: url(http:\/\/energia.imdea.org\/wp-content\/uploads\/2022\/04\/cabe-proyectos02.jpg);background-repeat: no-repeat;background-attachment: scroll;background-position: top left;background-size: cover;}.tatsu-h25u8z2cwv2kj2v6 .tatsu-bg-blur{background-repeat: no-repeat;background-attachment: scroll;background-position: top left;background-size: cover;}.tatsu-h25u8z2cwv2kj2v6.tatsu-section{margin: 0px 0px 80px 0px;}.tatsu-h25u8z2cwv2kj2v6 .tatsu-section-offset-wrap{transform: translateY(-0px);}.tatsu-h25u8z2cwv2kj2v6 > .tatsu-bottom-divider{z-index: 9999;}.tatsu-h25u8z2cwv2kj2v6 > .tatsu-top-divider{z-index: 9999;}.tatsu-h25u8z2cwv2kj2v6 .tatsu-section-overlay{mix-blend-mode: normal;}<\/style><\/div><div  class=\"tatsu-h1njcge49p3puiqb tatsu-section  tatsu-bg-overlay   tatsu-clearfix\" data-title=\"\"  data-headerscheme=\"background--dark\"><div class='tatsu-section-pad clearfix' data-padding='{\"d\":\"0px 0px 90px 0px\"}' data-padding-top='0px'><div class=\"tatsu-row-wrap  tatsu-wrap tatsu-row-one-col tatsu-row-has-one-cols tatsu-medium-gutter tatsu-reg-cols  tatsu-clearfix tatsu-h1njcge4ch3d08b9\" ><div  class=\"tatsu-row \" ><div  class=\"tatsu-column  tatsu-bg-overlay tatsu-one-col tatsu-column-image-none tatsu-column-effect-none  tatsu-h1njcge4ex9pofqn\"  data-parallax-speed=\"0\" style=\"\"><div class=\"tatsu-column-inner \" ><div class=\"tatsu-column-pad-wrap\"><div class=\"tatsu-column-pad\" ><div  class=\"tatsu-module tatsu-text-block-wrap tatsu-h1njcge4hc4dgqla  \"><div class=\"tatsu-text-inner tatsu-align-center  clearfix\" ><style>.tatsu-h1njcge4hc4dgqla.tatsu-text-block-wrap .tatsu-text-inner{width: 100%;text-align: left;}<\/style>\n<p>The blood-brain barrier (BBB) severely constrains drug delivery to the brain, limiting the treatment of neurological diseases. Despite the significant progress of current nanomedicines, their clinical application is limited by the lack of effective <em>in vivo<\/em> delivery platforms. To cope with this challenge, NeuroMOF proposes the development of a biosafe and efficient tailored drug delivery system (DDS) based on <strong>nanoscaled porous Metal Organic Frameworks (nanoMOFs)<\/strong> for brain delivery. To achieve this goal, two original targeting strategies will be undertaken to pass through the BBB: targeting by external functionalization with BBB-specific ligands &#038; enzyme immobilization known as <strong>MOF targeting<\/strong> &#038; <strong>MOF motion<\/strong> (self-propelled nanomotors), facing up the challenge to control the orientation, stability, density and distribution (symmetric\/asymmetric) of the surface agent. The most promising nanoMOF prototypes will be selected based on the outcomes achieved on the biodistribution, biocompatibility and bioactivity assays performed on <em>in vitro<\/em> and <em>in vivo<\/em> BBB models.<\/p>\n<p>To reach the challenging objective, a collaboration has been implemented between the IMDEA Research group of Advanced Porous Materials Unit (APMU), led by P. Horcajada and recognized as expert in the synthesis, characterization and bioapplication of nanoMOFs and the Molecular Bionics Labs, led by G. Battaglia (University College London-UK and IBEC-Barcelona Spain) in which specialists worked on the design and evaluation of chemotactic delivery systems to cross the CNS barriers by using adapted in vitro and in vivo BBB models. Dr. Tania Hidalgo, as MSCA fellow, will achieve 3 secondments in this latter laboratory in order to perform <em>in vitro<\/em> and <em>in vivo<\/em> assays.<\/p>\n<p>This highly innovative research will open new avenues for the bio &#038; technological application of nanoMOFs, promoting the development of innovative approaches for targeting more effective neurological therapies.<\/p>\n<p><strong>Investigators: <\/strong>Tania Hidalgo (Fellow) &#038; Patricia Horcajada (Supervisor)<\/p>\n<p><strong>Hosting\/Supervisor Secondment: <\/strong>Molecular Bionics Lab, University College London (London, UK) &#038; Institute for Bioengineering of Catalonia (Barcelona, Spain)| Supervisor: Giuseppe Battaglia.<\/p>\n<p><strong>Funding Institution\/Program:<\/strong> This project has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement No 897678.<\/p>\n<p><strong>Call:<\/strong> Marie Sk\u0142odowska-Curie Individual Fellowships (H2020-MSCA-IF-2019)<\/p>\n<p><strong>Type of action:<\/strong> Standard European Fellowships (MSCA-IF-EF-ST)<\/p>\n<p><strong>Period:<\/strong> July 2021-June 2023<\/p>\n<\/div><\/div><div  class=\"tatsu-single-image tatsu-module tatsu-image-lazyload tatsu-rJZ46wcUc  \" ><div class=\"tatsu-single-image-inner \" style=\"width : 304px;\" ><div class = \"tatsu-single-image-padding-wrap\" style = \"padding-bottom : 40.789473684211%;\" ><\/div><img class = \"tatsu-gradient-border\" alt = \"\" title = \"funded\" data-src = \"http:\/\/energia.imdea.org\/wp-content\/uploads\/2023\/01\/funded.jpg\" src =\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR42mNkYAAAAAYAAjCB0C8AAAAASUVORK5CYII=\"  \/><\/div><style>.tatsu-rJZ46wcUc .tatsu-single-image-inner{border-style: solid;max-width: 100%;}.tatsu-rJZ46wcUc.tatsu-single-image{transform: translate3d(0px,0px, 0);}<\/style><\/div><\/div><\/div><div class = \"tatsu-column-bg-image-wrap\"><div class = \"tatsu-column-bg-image\" ><\/div><\/div><div class=\"tatsu-overlay tatsu-column-overlay tatsu-animate-none\" ><\/div><\/div><style>.tatsu-row > .tatsu-h1njcge4ex9pofqn.tatsu-column{width: 100%;}.tatsu-h1njcge4ex9pofqn.tatsu-column > .tatsu-column-inner > .tatsu-column-overlay{mix-blend-mode: normal;}.tatsu-h1njcge4ex9pofqn > .tatsu-column-inner > .tatsu-top-divider{z-index: 9999;}.tatsu-h1njcge4ex9pofqn > .tatsu-column-inner > .tatsu-bottom-divider{z-index: 9999;}.tatsu-h1njcge4ex9pofqn > .tatsu-column-inner > .tatsu-left-divider{z-index: 9999;}.tatsu-h1njcge4ex9pofqn > .tatsu-column-inner > .tatsu-right-divider{z-index: 9999;}<\/style><\/div><\/div><\/div><\/div><div class=\"tatsu-section-background-wrap\"><div class = \"tatsu-section-background\" ><\/div><\/div><div class=\"tatsu-overlay tatsu-section-overlay\"><\/div><style>.tatsu-h1njcge49p3puiqb .tatsu-section-pad{padding: 0px 0px 90px 0px;}.tatsu-h1njcge49p3puiqb > .tatsu-bottom-divider{z-index: 9999;}.tatsu-h1njcge49p3puiqb > .tatsu-top-divider{z-index: 9999;}.tatsu-h1njcge49p3puiqb .tatsu-section-overlay{mix-blend-mode: normal;}<\/style><\/div>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"http:\/\/energia.imdea.org\/en\/porfolio\/6468\/\" class=\"more-link style1-button\">Read More<\/a><\/p>","protected":false},"author":3,"featured_media":6469,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","format":"standard","meta":{"_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"portfolio_category":[76],"portfolio_tag":[],"class_list":["post-6468","portfolio","type-portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-internacionales-finalizados-ingles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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